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产品信息
PA5-86696
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 217-262 of Human Caspase 7.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2803456
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
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生物信息学
蛋白别名: Apoptotic protease Mch-3; CASP-7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; CMH-1; Cysteine protease LICE2; ICE-LAP3; ICE-like apoptotic protease 3
基因别名: AI314680; CASP-7; CASP7; caspase-7; CMH-1; ICE-IAP3; ICE-LAP3; LICE2; mCASP-7; MCH3
UniProt ID: (Human) P55210, (Mouse) P97864
Entrez Gene ID: (Human) 840, (Rat) 64026, (Mouse) 12369
cysteine-type endopeptidase activity
protein binding
cysteine-type peptidase activity
cysteine-type endopeptidase activity involved in execution phase of apoptosis
aspartic-type endopeptidase activity
cysteine-type endopeptidase activity involved in apoptotic process
peptidase activity
hydrolase activity
protease
proteolysis
apoptotic process
cellular component disassembly involved in execution phase of apoptosis
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
execution phase of apoptosis
release of cytochrome c from mitochondria
heart development
aging
response to UV
protein processing
positive regulation of neuron apoptotic process
neuron apoptotic process
