Search Thermo Fisher Scientific
Reconstitution: 1 X 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell recognition molecule Caspr2; contactin associated protein-like 2; Contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV
基因别名: 5430425M22Rik; AUTS15; CASPR2; CDFE; CNTNAP2; KIAA0868; mKIAA0868; NRXN4; PTHSL1
UniProt ID: (Human) Q9UHC6, (Mouse) Q9CPW0
Entrez Gene ID: (Human) 26047, (Rat) 500105, (Mouse) 66797