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CDC25a is a member of the CDC25 family of phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. CDC25a is required for progression through G1 and S phases of the cell cycle. CDC25a activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CDC25 isoform A1-CAG; CDC25A2-CAG isoform; Dual specificity phosphatase Cdc25A; EC 3.1.3.48; M-phase inducer phosphatase 1; MPIP1
基因别名: CDC25A; CDC25A2; Cdc25m3; D9Ertd393e
UniProt ID: (Human) P30304, (Rat) P48965, (Mouse) P48964
Entrez Gene ID: (Human) 993, (Rat) 171102, (Mouse) 12530