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Invitrogen
Claudin 5 Recombinant Rabbit Monoclonal Antibody (JM11-22)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Claudin 5 Antibody (MA5-32614) in ICC/IF
Immunofluorescence analysis of CLDN5 was performed using 90% confluent log phase HUVEC cells. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with Claudin 5 Recombinant Rabbit Monoclonal Antibody (JM11-22) (Product # MA5-32614) at 1:100 dilution in 0.1% BSA, ... View More
产品信息
MA5-32614
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM11-22
抗原
Synthetic peptide within Human Claudin 5 aa 191-214
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809891
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Claudin-5; TMDVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
基因别名: AWAL; BEC1; CLDN5; CPETRL1; TMVCF
UniProt ID: (Human) O00501
Entrez Gene ID: (Human) 7122
outflow tract morphogenesis
cell-cell junction assembly
transforming growth factor beta receptor signaling pathway
learning
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
palate development
face morphogenesis
positive regulation of establishment of endothelial barrier
