Search Thermo Fisher Scientific
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Claudin-6; Claudin6; CLD6; Skullin; tight junction molecule claudin 6
基因别名: AL024037; CLDN6; UNQ757/PRO1488
UniProt ID: (Human) P56747, (Mouse) Q9Z262
Entrez Gene ID: (Human) 9074, (Mouse) 54419, (Rat) 287098