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Invitrogen
Cofilin Monoclonal Antibody (GT217)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 9
Cofilin Antibody (MA5-27737) in ICC/IF
Cofilin Monoclonal Antibody (GT217) detects Cofilin 1 protein at cell membrane by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: Cofilin 1 stained by Cofilin Monoclonal Antibody (GT217) (Product # MA5-27737) diluted at 1:500. Blue: Fluoroshield with DAPI .
产品信息
MA5-27737
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
GT217
抗原
Recombinant protein encompassing a sequence within the center region of human Cofilin 1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7, with 20% glycerol
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2735151
产品详细信息
Positive Control: 293T, A431, HeLa, HepG2, PC-12, Rat-2, Neuro2A, C8D30, NIH-3T3, Raw264.7, C2C12
Predicted Reactivity: Pig (99%), Sheep (99%), Rhesus Monkey (99%), Bovine (99%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Required for neural tube morphogenesis and neural crest cell migration.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 18 kDa phosphoprotein; CFL-1; COF1; cofilin 1 (non-muscle); Cofilin, non-muscle isoform; Cofilin-1; Cofilin1; epididymis secretory protein Li 15; p18
基因别名: AA959946; CFL; CFL1; Cof; cofilin; HEL-S-15; n-cofilin
UniProt ID: (Human) P23528, (Rat) P45592, (Mouse) P18760
Entrez Gene ID: (Human) 1072, (Rat) 29271, (Mouse) 12631
cytoskeleton organization
Rho protein signal transduction
response to virus
regulation of cell morphogenesis
actin cytoskeleton organization
actin filament depolymerization
negative regulation of apoptotic process
positive regulation by host of viral process
regulation of dendritic spine morphogenesis
mitotic cytokinesis
neural crest cell migration
neural fold formation
protein phosphorylation
protein import into nucleus
actin filament organization
establishment of cell polarity
cell projection organization
positive regulation of actin filament depolymerization
response to amino acid
negative regulation of cell size
movement of cell or subcellular component
