Invitrogen

Connexin 40 Polyclonal Antibody

Connexin 40 Antibody in Immunohistochemistry (IHC)

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Connexin 40 Antibody (36-5000) in IHC

Immunohistochemical staining of mouse heart using Rb anti-Connexin 40 (Mid, Product # 36-5000). Image courtesy of James I. Nagy, PhD, University of Manitoba, Canada.

Connexin 40 Antibody in Western Blot (WB)

Connexin 40 Antibody in Immunocytochemistry (ICC/IF)

Product Image Gallery

产品信息

36-5000

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

查看3篇已发表文章 3篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

Assay-dependent

免疫细胞化学 (ICC/IF)

查看4篇已发表文章 4篇已发表文章

产品规格

种属反应

Mouse

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide derived from an internal region of the mouse Connexin 40 (Cx40) protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533264

靶标信息

Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Cardiomyocyte Expression of ZO-1 Is Essential for Normal Atrioventricular Conduction but Does Not Alter Ventricular Function.

Circulation research

Zhang J,Vincent KP,Peter AK,Klos M,Cheng H,Huang SM,Towne JK,Ferng D,Gu Y,Dalton ND,Chan Y,Li R,Peterson KL,Chen J,McCulloch AD,Knowlton KU,Ross RS

36-5000 was used in Western Blot to determine the function of cardiac myocyte ZO-1 (Zonula occludens-1) in the intact heart, given its binding to other cardiac myocyte proteins involved in normal cardiac conduction and function.

Fri Jul 03 00:00:00 EDT 2020

Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors.

Stem cells international

Yang J,Kaur K,Ong LL,Eisenberg CA,Eisenberg LM

36-5000 was used in immunocytochemistry to study the effect of G9a histone methyltransferase inhibitor on bone marrow mesenchymal stem cells

Fri Jun 19 00:00:00 EDT 2015

Re-evaluation of connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus.

The European journal of neuroscience

Bautista W,Rash JE,Vanderpool KG,Yasumura T,Nagy JI

36-5000 was used in immunocytochemistry to characterize connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus

Sat Mar 01 00:00:00 EST 2014

Re-evaluation of connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus.

The European journal of neuroscience

Bautista W,Rash JE,Vanderpool KG,Yasumura T,Nagy JI

36-5000 was used in immunocytochemistry to characterize connexins associated with motoneurons in rodent spinal cord, sexually dimorphic motor nuclei and trigeminal motor nucleus

Sat Mar 01 00:00:00 EST 2014

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.

Nature communications

Zhang L,Chen X,Sharma P,Moon M,Sheftel AD,Dawood F,Nghiem MP,Wu J,Li RK,Gramolini AO,Sorensen PH,Penninger JM,Brumell JH,Liu PP

36-5000 was used in western blot to demonstrate that HACE protects the heart under pressure stress by regulating protein degradation.

Tue Mar 11 00:00:00 EDT 2014

Contribution of intracellular calcium and pH in ischemic uncoupling of cardiac gap junction channels formed of connexins 43, 40, and 45: a critical function of C-terminal domain.

PloS one

Sahu G,Bera AK

36-5000 was used in immunocytochemistry to examine the vulnerability of different cardiac gap junction channels formed of connexins 43, 40, and 45 to simulated ischemia.