Invitrogen

Connexin 40 Polyclonal Antibody

查看其他5个Connexin 40抗体
说明书
实验方案
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说明书
实验方案
技术支持

产品信息

PA5-34964

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to a region within amino acids 136 and 235 of Connexin 40
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2552313

产品详细信息

Recommended positive controls: 293T, A431, HepG2.

Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Rabbit (100%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: connexin 40; Connexin-40; Cx40; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5; gap junction protein alpha 5 40kDa

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基因别名: 5730555N10Rik; ATFB11; Cnx40; CX40; Cxn-40; Gja-5; GJA5

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UniProt ID: (Human) P36382, (Mouse) Q01231

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Entrez Gene ID: (Human) 2702, (Mouse) 14613

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功能
gap junction hemi-channel activity connexin binding gap junction channel activity involved in cardiac conduction electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling gap junction channel activity gap junction
参与通路
skeletal system development angiogenesis negative regulation of glomerular filtration outflow tract morphogenesis endothelium development cardiac conduction system development mitral valve development pulmonary valve formation ventricular septum development atrial septum development septum primum development atrial ventricular junction remodeling potassium ion transport cell communication by chemical coupling positive regulation of cell communication by chemical coupling gap junction assembly embryonic limb morphogenesis embryonic heart tube development foramen ovale closure negative regulation of blood pressure positive regulation of vasoconstriction positive regulation of vasodilation artery morphogenesis protein oligomerization transmembrane transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization ventricular septum morphogenesis atrial septum morphogenesis ventricular cardiac muscle cell action potential SA node cell action potential AV node cell to bundle of His cell communication by electrical coupling bundle of His cell to Purkinje myocyte communication by electrical coupling cell communication by electrical coupling involved in cardiac conduction regulation of heart rate by cardiac conduction regulation of AV node cell action potential regulation of bundle of His cell action potential regulation of Purkinje myocyte action potential regulation of atrial cardiac muscle cell action potential regulation of renin secretion into blood stream regulation of membrane depolarization during cardiac muscle cell action potential vasomotion blood vessel development renal system process involved in regulation of systemic arterial blood pressure regulation of systemic arterial blood pressure cell communication cell communication by electrical coupling regulation of vasodilation cardiac conduction cell communication involved in cardiac conduction AV node cell to bundle of His cell communication
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