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Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. Tissue specificity: Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord. Similarity: Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: axonal-associated cell adhesion molecule; BIG-1; BIG-2; brain-derived immunoglobulin superfamily molecule; Brain-derived immunoglobulin superfamily protein 1; Brain-derived immunoglobulin superfamily protein 2; contactin 3 (plasmacytoma associated); Contactin-3; Contactin-4; Contactin-5; Contactin-6; hNB-2; hNB-3; mNB-3; neural adhesion molecule; neural cell adhesion protein BIG-2; Neural recognition molecule NB-2; Neural recognition molecule NB-3; Plasmacytoma-associated neuronal glycoprotein; Plasmacytoma-associated neuronal glycoprotein (neural cell adhesion molecule BIG-1)
基因别名: 6720426O10Rik; 9630050B05; A830025P08Rik; AXCAM; BIG-1; BIG-2; CNTN3; CNTN4; CNTN5; CNTN6; Gm507; HNB-2s; KIAA1496; Kiaa3024; NB-2; NB-3; NB3; PANG; PCS
UniProt ID: (Human) Q9P232, (Human) Q8IWV2, (Human) O94779, (Human) Q9UQ52, (Mouse) Q07409, (Rat) Q62682, (Rat) Q62845, (Mouse) Q69Z26, (Mouse) P68500, (Rat) P97527, (Mouse) Q9JMB8, (Rat) P97528
Entrez Gene ID: (Human) 5067, (Human) 152330, (Human) 53942, (Human) 27255, (Mouse) 18488, (Rat) 54279, (Rat) 116658, (Mouse) 269784, (Mouse) 244682, (Rat) 114589, (Mouse) 53870, (Rat) 27256