Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-22700
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide made to an N-terminal portion of the murine cripto protein sequence (between residues 1-50).
偶联物
激发/发射光谱
492/519 nm
查看光谱
形式
Liquid
浓度
0.94 mg/mL
纯化类型
Antigen affinity chromatography
保存液
50mM sodium borate
内含物
no preservative
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11152986
产品详细信息
In Western blot a band is seen at ~18 kDa representing the core form of Cripto1, and at ~36 kDa reporesenting the glycosylated/ post-translationally modified form.
Suggested positive control: MDA-MB231 (human breast cancer) lysates.
靶标信息
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CRGF; Cripto growth factor; Cripto, EGF-CFC family member; Cripto-1; Cripto-1 growth factor; Cripto-3; Epidermal growth factor-like Cripto protein; Epidermal growth factor-like cripto protein CR1; Protein Cripto; TDGF2; Teratocarcinoma-derived growth factor; Teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
基因别名: CR; CR1; CRGF; CRIPTO; CRIPTO-1; TDGF1
UniProt ID: (Human) P13385, (Mouse) P51865
Entrez Gene ID: (Human) 6997, (Mouse) 21667
activation of MAPK activity
morphogenesis of a branching structure
cell migration involved in sprouting angiogenesis
epidermal growth factor receptor signaling pathway
heart development
positive regulation of cell proliferation
anterior/posterior axis specification, embryo
embryo development
regulation of signal transduction
positive regulation of endothelial cell migration
peptidyl-serine phosphorylation
cell differentiation
positive regulation of cell migration
mammary gland development
somatic stem cell population maintenance
cellular response to hepatocyte growth factor stimulus
negative regulation of apoptotic process
cellular response to fibroblast growth factor stimulus
positive regulation of peptidyl-tyrosine phosphorylation
cellular response to interferon-gamma
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
vasculogenesis
in utero embryonic development
positive regulation of cell-matrix adhesion
gastrulation
anterior/posterior axis specification
regulation of cell migration
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
nodal signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
cardiac muscle cell differentiation
canonical Wnt signaling pathway
