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Immunogen sequence: DTTTLIEPVS RSRQGSGVIL RQEEAEYVRA LFDFNGNDEE DLPF
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adapter molecule crk; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAX-interacting protein 2; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38alpha Exip; Proto-oncogene c-Crk; SAPK2a; Stress-activated protein kinase 2a; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene-like protein
基因别名: CRK; CRKII; CSBP; CSBP1; CSBP2; CSPB1; EXIP; MAPK14; MXI2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A
UniProt ID: (Human) P46108, (Human) Q16539
Entrez Gene ID: (Human) 1398, (Human) 1432
分子生物学功能:
scaffold/adaptor protein
non-receptor serine/threonine protein kinase