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Immunogen sequence: PSVLALSIIA LEIQAQKCVE LTEGIECLQK HSKINGRDLT FWQELVSKCL TEYSSNKCSK PNVQKLKWIV SGRTARQLKH SYYRITHLPT IPEMVP; Positive Samples: Mouse kidney, Mouse skeletal muscle; Cellular Location: Nucleus
Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2- cyclin B complex controls the G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. The G1 to S transition, however, appears to be controlled by the G1 cyclins. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cyclin-G; Cyclin-G1
基因别名: AI314029; CCNG; CCNG1; CYCG; CYCG1
UniProt ID: (Human) P51959, (Mouse) P51945, (Rat) P39950
Entrez Gene ID: (Human) 900, (Mouse) 12450, (Rat) 25405
分子生物学功能:
kinase activator