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Cyclophilin B Antibody (MA5-49248) in ICC/IF
Immunocytochemistry analysis of Cyclophilin B in U2OS cells. Heat mediated antigen retrieval was performed in EDTA buffer (pH8.0, epitope retrieval solution). The cells were blocked with 10% goat serum. Samples were then incubated in Cyclophilin B Monoclonal antibody (Product # MA5-49248) using a dilution of 2 μg/mL. Biotin conjugated goat anti-mouse IgG was used as secondary antibody and incubated for 30 m... View More
产品信息
MA5-49248
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
11C11
抗原
E. coli-derived human Cyclophilin B recombinant protein (Position: K158-E216).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074906
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
靶标信息
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cyclophilin B; cyclophilin-like protein; Cyp B; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP
基因别名: AA408962; AA553318; AI844835; Cphn-2; Cphn2; CyP-20b; CYP-S1; CYPB; HEL-S-39; OI9; PPIB; SCYLP
UniProt ID: (Human) P23284, (Rat) P24368, (Mouse) P24369
Entrez Gene ID: (Human) 5479, (Rat) 64367, (Mouse) 19035
protein peptidyl-prolyl isomerization
positive regulation of multicellular organism growth
positive regulation by host of viral process
positive regulation by host of viral genome replication
protein stabilization
bone development
chaperone-mediated protein folding
regulation of post-translational protein modification
nuclear transport
protein folding
