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Immunogen sequence: LSSSQFSSGS QSSRDVTSSS RQIRTKVMDV HDGKVVSTHE QVLRTKN
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CK-14; cytokeratin 14; Cytokeratin-14; epidermolysis bullosa simplex, Dowling-Meara, Koebner; K14; keratin 14, type I; keratin complex 1, acidic, gene 14; Keratin, type I cytoskeletal 14; Keratin-14; Koebner
基因别名: AI626930; CK14; EBS3; EBS4; K14; Krt-1.14; Krt1-14; KRT14; NFJ
UniProt ID: (Human) P02533, (Mouse) Q61781
Entrez Gene ID: (Human) 3861, (Mouse) 16664