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Proteintech

D2HGDH Polyclonal Antibody

16 篇参考文献

查看其他5个D2HGDH抗体

说明书

实验方案

技术支持

货号 13895-1-AP

此产品在中国无法购买

150 µL

说明书

实验方案

技术支持

抗体检测数据 (11)

Application

D2HGDH Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 11

D2HGDH Antibody (13895-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 13895-1-AP (D2HGDH antibody) at dilution of 1:100 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

D2HGDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

D2HGDH Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

13895-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看10篇已发表文章 10篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫细胞化学 (ICC/IF)

1:20-1:200

查看2篇已发表文章 2篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

不适用 (N/A)

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

D2HGDH Fusion Protein Ag4857 (1-286 aa encoded by BC036604)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.27 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MLPRRPLAW PAWLLRGAPG AAGSWGRPVG PLARRGCCSA PGTPEVPLTR ERYPVQRLPF STVSKQDLAA FERIVPGGVV TDPEALQAPN VDWLRTLRGC SKVLLRPRTS EEVSHILRHC HERNLAVNPQ GGNTGMVGGS VPVFDEIILS TARMNRVLSF HSVSGILVCQ AGCVLEELSR YVEERDFIMP LDLGAKGSCH IGGNVATNAG GLRFLRYGSL HGTVLGLEVV LADGTVLDCL TSLRKDNTGY DLKQLFIGSE GTLGIITTVS ILCPPKPRAV NVAFLGC (1-286 aa encoded by BC036604)

靶标信息

This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase.

Cell reports

Liu Y,Wang M,Guo Y,Wang L,Guo W

Tue Feb 28 00:00:00 UTC 2023

D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase.

Cell reports

Liu Y,Wang M,Guo Y,Wang L,Guo W

Tue Feb 28 00:00:00 UTC 2023

Oncometabolite d-2HG alters T cell metabolism to impair CD8⁺ T cell function.

Science (New York, N.Y.)

Notarangelo G,Spinelli JB,Perez EM,Baker GJ,Kurmi K,Elia I,Stopka SA,Baquer G,Lin JR,Golby AJ,Joshi S,Baron HF,Drijvers JM,Georgiev P,Ringel AE,Zaganjor E,McBrayer SK,Sorger PK,Sharpe AH,Wucherpfennig KW,Santagata S,Agar NYR,Suvà ML,Haigis MC

Fri Sep 30 00:00:00 UTC 2022

MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases.

Leukemia

Lin AP,Qiu Z,Ethiraj P,Sasi B,Jaafar C,Rakheja D,Aguiar RCT

Fri Apr 01 00:00:00 UTC 2022

Urinary 2-Hydroxyglutarate Enantiomers Are Markedly Elevated in a Murine Model of Type 2 Diabetic Kidney Disease.

Metabolites

Baek J,Pennathur S

Wed Jul 21 00:00:00 UTC 2021

D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation.

Histology and histopathology

Hayashi C,Takagi K,Sato A,Yamaguchi M,Minemura H,Miki Y,Harada-Shoji N,Miyashita M,Sasano H,Suzuki T

Fri Oct 01 00:00:00 UTC 2021

D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation.

Histology and histopathology

Hayashi C,Takagi K,Sato A,Yamaguchi M,Minemura H,Miki Y,Harada-Shoji N,Miyashita M,Sasano H,Suzuki T

Fri Oct 01 00:00:00 UTC 2021

MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.

Cell chemical biology

Qiu Z,Lin AP,Jiang S,Elkashef SM,Myers J,Srikantan S,Sasi B,Cao JZ,Godley LA,Rakheja D,Lyu Y,Zheng S,Madesh M,Shiio Y,Dahia PLM,Aguiar RCT

Thu May 21 00:00:00 UTC 2020

Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations.

Scientific reports

Berger RS,Ellmann L,Reinders J,Kreutz M,Stempfl T,Oefner PJ,Dettmer K

Wed May 15 00:00:00 UTC 2019

D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants.

Human mutation

Pop A,Struys EA,Jansen EEW,Fernandez MR,Kanhai WA,van Dooren SJM,Ozturk S,van Oostendorp J,Lennertz P,Kranendijk M,van der Knaap MS,Gibson KM,van Schaftingen E,Salomons GS

Mon Jul 01 00:00:00 UTC 2019

Hypoxia Induces Production of L-2-Hydroxyglutarate.

Cell metabolism

Intlekofer AM,Dematteo RG,Venneti S,Finley LW,Lu C,Judkins AR,Rustenburg AS,Grinaway PB,Chodera JD,Cross JR,Thompson CB

Tue Aug 04 00:00:00 UTC 2015

Hypoxia Induces Production of L-2-Hydroxyglutarate.

Cell metabolism

Intlekofer AM,Dematteo RG,Venneti S,Finley LW,Lu C,Judkins AR,Rustenburg AS,Grinaway PB,Chodera JD,Cross JR,Thompson CB

Tue Aug 04 00:00:00 UTC 2015

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.

Cell metabolism

Oldham WM,Clish CB,Yang Y,Loscalzo J

Tue Aug 04 00:00:00 UTC 2015

Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.

Cell metabolism

Oldham WM,Clish CB,Yang Y,Loscalzo J

Tue Aug 04 00:00:00 UTC 2015

D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.

Nature communications

Lin AP,Abbas S,Kim SW,Ortega M,Bouamar H,Escobedo Y,Varadarajan P,Qin Y,Sudderth J,Schulz E,Deutsch A,Mohan S,Ulz P,Neumeister P,Rakheja D,Gao X,Hinck A,Weintraub ST,DeBerardinis RJ,Sill H,Dahia PL,Aguiar RC