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DARC Antibody (PA5-47861) in IHC (F)
Immunohistochemical analysis of DARC in perfusion fixed frozen sections of mouse skin. Samples were incubated with DARC polyclonal antibody (Product # PA5-47861) using a dilution of 0.5 µg/mL overnight at 4 °C followed by NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to the hair follicle.
产品信息
PA5-47861
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse DARC Met1-Pro61, Ala115-Cys127, Ser186-Lys205, Tyr264-Asn285
偶联物
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2576815
产品详细信息
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
ACKR1 or DARC is an atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades resulting instead in chemokine sequestration, degradation, or transcytosis. ACKR1 is also known as an interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. It has a promiscuous chemokine-binding profile by interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. ACKR1 also acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and for the malaria parasites P.vivax and P.knowlesi.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Atypical chemokine receptor 1; CD234; CD234 antigen; CTA-134P22.3; Duffy Antigen; Duffy antigen receptor for chemokines; Duffy antigen/chemokine receptor; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; Fy Antigen; FYDuffy blood group; glycoprotein D; GPDWBCQ1; HGNC:4035; OTTHUMP00000060081
基因别名: AA162249; Ackr1; CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD
UniProt ID: (Mouse) Q9QUI6
Entrez Gene ID: (Rat) 689105, (Mouse) 13349
