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Immunogen sequence: ACVRPTHPLR SFANPLLPPP MSAIEPKVPY TPLLSQPGPT LPKTHVKTAS LGLAGKARSP LLPVSVPTAP EVSEESHKPT EDSANVYEQD DLSEQMAS
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Colorectal cancer suppressor; colorectal tumor suppressor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; Netrin receptor DCC; putative colorectal tumor suppressor; Tumor suppressor protein DCC
基因别名: CRC18; CRCR1; DCC; IGDCC1; MRMV1; NTN1R1
UniProt ID: (Human) P43146
Entrez Gene ID: (Human) 1630