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Invitrogen
DCK Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 12
DCK Antibody (PA5-27787) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of DCK was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: DCK Polyclonal Antibody (Product # PA5-27787) diluted at 1:500. Red: Phalloidin, a cytoskeleton marker. Scale bar = 10 µm.
产品信息
PA5-27787
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 260 of Human DCK
偶联物
形式
Liquid
浓度
1.41 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545263
产品详细信息
Recommended positive controls: 293T, A431, HeLa, HepG2, A549, H1299, PC-12, Rat2, DCK-transfected 293T.
Predicted reactivity: Mouse (93%), Rat (92%), Chicken (82%), Rhesus Monkey (96%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: dCK; Deoxyadenosine kinase; Deoxycytidine kinase; Deoxyguanosine kinase; deoxynucleoside kinase
基因别名: DCK
UniProt ID: (Human) P27707, (Mouse) P43346, (Rat) P48769
Entrez Gene ID: (Human) 1633, (Mouse) 13178, (Rat) 79127
pyrimidine nucleotide metabolic process
deoxyribonucleoside monophosphate biosynthetic process
nucleotide biosynthetic process
phosphorylation
pyrimidine nucleoside salvage
purine-containing compound salvage
nucleobase-containing compound metabolic process
drug metabolic process
deoxycytidine metabolic process
