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Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: dCK; Deoxyadenosine kinase; Deoxycytidine kinase; Deoxyguanosine kinase; deoxynucleoside kinase
基因别名: DCK
UniProt ID: (Human) P27707
Entrez Gene ID: (Human) 1633
分子生物学功能:
nucleotide kinase