Proteintech

DCLK1 Polyclonal Antibody

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DCLK1 Antibody (21699-1-AP) in WB

Mouse brain tissue were subjected to SDS PAGE followed by western blot with 21699-1-AP (DCLK1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

DCLK1 Antibody in Immunoprecipitation (IP)

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产品信息

21699-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化 (IHC)

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免疫细胞化学 (ICC/IF)

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流式细胞分析 (Flow)

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免疫沉淀 (IP)

0.5-4.0 µg

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

DCLK1 Fusion Protein Ag16292 (623-729 aa encoded by BC152456)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.23 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: LITMMLLVD VDQRFSAVQV LEHPWVNDDG LPENEHQLSV AGKIKKHFNT GPKPNSTAAG VSVIALDHGF TIKRSGSLDY YQQPGMYWIR PPLLIRRGRF SDEDATRM (623-729 aa encoded by BC152456)

靶标信息

DCAMKL1 (DCLK1) serine/threonine kinase or DCLK1 or doublecortin-like kinase 1 contains two N-terminal doublecortin domains (which bind microtubules and regulate microtubule polymerization), a C-terminal serine/threonine protein kinase domain (which shows substantial homology to Ca2+/calmodulin-dependent protein kinase), and a serine/proline-rich domain in between the doublecortin and the protein kinase domains (which mediates multiple protein-protein interactions). DCAMKL1 is a microtubule-associated kinase that can undergo autophosphorylation. DCAMKL1 has microtubule-polymerizing activity that is independent of its protein kinase activity. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Calcium/calmodulin-dependent protein kinase type I-like CPG16; CLICK-I beta; double cortin and calcium/calmodulin-dependent protein kinase-like 1; doublecortin and calcium/calmodulin-dependent protein kinase-like 1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1; RP11-113P14.1; Serine/threonine-protein kinase DCLK1

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基因别名: 1700113D08Rik; 2810480F11Rik; AI836758; Ania4; CL1; Click-I; CLICK1; Cpg16; DCAMKL1; DCDC3A; Dcl; DCLK; DCLK1; KIAA0369; mKIAA0369

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UniProt ID: (Human) O15075, (Mouse) Q9JLM8, (Rat) O08875

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Entrez Gene ID: (Human) 9201, (Mouse) 13175, (Rat) 83825

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功能

protein kinase activity protein serine/threonine kinase activity receptor signaling protein activity ATP binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase

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