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DCLRE1B Antibody (PA5-93234) in WB
Western blot analysis of DCLRE1B in extracts of THP-1 cells. Samples were incubated with DCLRE1B Polyclonal antibody (Product # PA5-93234) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
产品信息
PA5-93234
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 323-532 of human DCLRE1B (NP_0737471)
偶联物
形式
Liquid
浓度
0.63 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2806683
产品详细信息
Immunogen sequence: VQQYMSSSSR KPSLLWLLER RLKRPRTQGV VFESPEESAD QSQADRDSKK AKKEKLSPWP ADLEKQPSHH PLRIKKQLFP DLYSKEWNKA VPFCESQKRV TMLTAPLGFS VHLRSTDEEF ISQKTREEIG LGSPLVPMGD DDGGPEATGN QSAWMGHGSP LSHSSKGTPL LATEFRGLAL KYLLTPVNFF QAGYSSRRFD QQVEKYHKPC; Positive Samples: THP-1; Cellular Location: Chromosome, Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, telomere
靶标信息
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 5' exonuclease Apollo; Beta-lactamase DCLRE1B; Beta-lactamase MBLAC2; DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1B protein; PSO2 homolog; SNM1 homolog B; SNMIB
基因别名: AI452214; APOLLO; DCLRE1B; mSNM1B; SNM1B; SNMIB
UniProt ID: (Human) Q9H816, (Mouse) Q8C7W7
Entrez Gene ID: (Human) 64858, (Mouse) 140917
cell cycle checkpoint
telomere maintenance
double-strand break repair via nonhomologous end joining
telomeric loop formation
protection from non-homologous end joining at telomere
telomeric 3' overhang formation
interstrand cross-link repair
nucleic acid phosphodiester bond hydrolysis
DNA repair
nucleotide-excision repair
cellular response to DNA damage stimulus
