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产品信息
PA5-78534
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human DCP1A. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2735710
产品详细信息
Positive Control: Target recombinant protein
Predicted Reactivity: Mouse (94%), Rat (93%), Pig (94%), Bovine (96%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF. The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DCP1 decapping enzyme homolog A; DCP1 decapping enzyme-like protein A; decapping enzyme hDcp1a; FLJ21691; mRNA-decapping enzyme 1A; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; Transcription factor SMIF
基因别名: DCP1A; HSA275986; Nbla00360; SMAD4IP1; SMIF
UniProt ID: (Human) Q9NPI6
Entrez Gene ID: (Human) 55802
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
deadenylation-dependent decapping of nuclear-transcribed mRNA
deadenylation-independent decapping of nuclear-transcribed mRNA
positive regulation of catalytic activity
regulation of mRNA stability
exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
protein localization to cytoplasmic stress granule
