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This antibody is specific to DDB1.
Immunogen sequence: MSYNYVVTA QKPTAVNGCV TGHFTSAEDL NLLIAKNTRL EIYVVTAEGL RPVKEVGMYG KIAVMELFRP KGESKDLLFI LTAKYNACIL EYKQSGESID IITRAHGNVQ DRIGRPSETG IIGIIDPECR MIGLRLYDGL FKVIPLDRDN KELKAFNIRL EELHVIDVKF LYGCQAPTIC FVYQDPQGRH VKTYEVSLRE KEFNKGPWKQ ENVEAEASMV IAVPEPFGGA IIIGQESITY HNGDKYLAIA PPIIKQSTIV CHNRVDPNGS RYLLGDMEGR LFMLLLEKEE QMDGTVTLKD LRVELLGETS IAECLTYLDN GVVFVGSRLG DSQLVKLNVD SNEQGSYVVA METFTNLGPI VDMCVVDLER QGQGQLVTCS GAFKEGSLRI IRNGIGIHEH A (1-400 aa encoded by BC011686)
The DNA damage-binding protein from HeLa cells is associated with polypeptides of relative mass 124,000 (DDB1) and 41,000 (DDB2) as determined by SDS-polyacrylamide gels. To test whether the DNA-repair defect in the subset of XPE patients that lack DNA damage-binding activity is caused by a defect in DDB, Keeney et al. (1994) injected purified human DDB protein into XPE cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: damage specific DNA binding protein 1; damage-specific DNA binding protein 1, 127kDa; Damage-specific DNA-binding protein 1; damage-specific DNA-binding protein, DNA repair; damaged-DNA recognition protein 1; DDB p127 subunit; DDBa; DNA damage-binding protein 1; DNA damage-binding protein a; DNA repair protein; HBV X-associated protein 1; UV-damaged DNA-binding factor; UV-damaged DNA-binding protein 1; UV-DDB 1; XAP-1; xeroderma pigmento; Xeroderma pigmentosum group E-complementing protein; XPCe; XPE-BF; XPE-binding factor
基因别名: 127kDa; AA408517; DDB1; DDBA; p127-Ddb1; UV-DDB1; XAP1; XPCE; XPE; XPE-BF
UniProt ID: (Human) Q16531, (Mouse) Q3U1J4
Entrez Gene ID: (Human) 1642, (Mouse) 13194, (Rat) 64470
分子生物学功能:
RNA processing factor