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产品信息
MA5-41581
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
C5
抗原
Recombinant protein Dickkopf Related Protein 1. The antigen corresponds to amino acid range 33-266 of the target protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899063
靶标信息
DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head-forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play important regulatory roles in the Wnt/beta-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/beta-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/beta-catenin signaling cascade. It has been suggested that by inhibiting Wnt/beta-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dickkopf 1 homolog; dickkopf related protein-1; Dickkopf-1; dickkopf-1 like; dickkopf-like protein 1; Dickkopf-related protein 1; Dickkopf1; hDkk-1; hDkk1; SK
基因别名: DKK-1; DKK1; SK; UNQ492/PRO1008
UniProt ID: (Human) O94907
Entrez Gene ID: (Human) 22943
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis involved in differentiation
endoderm formation
mesoderm formation
hair follicle development
regulation of receptor internalization
negative regulation of Wnt signaling pathway
embryonic limb morphogenesis
negative regulation of BMP signaling pathway
forebrain development
negative regulation of protein binding
response to retinoic acid
negative regulation of peptidyl-serine phosphorylation
negative regulation of mesodermal cell fate specification
regulation of endodermal cell fate specification
negative regulation of skeletal muscle tissue development
negative regulation of synapse assembly
regulation of synaptic transmission, glutamatergic
face morphogenesis
negative regulation of pathway-restricted SMAD protein phosphorylation
motor learning
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway
Wnt signaling pathway involved in somitogenesis
extracellular negative regulation of signal transduction
negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
regulation of dopaminergic neuron differentiation
midbrain morphogenesis
negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
negative regulation of cardiac muscle cell differentiation
