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Immunogen sequence: LVCACAPGYM GARCEFPVHP DGASALPAAP PGLRPGDPQR YLLPPALGLL
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 86%; Human: 100%; Mouse: 79%; Pig: 93%
Delta-like protein 3 (DLL3) is a ligand for the Notch signaling pathway. It inhibits primary neurogenesis. DLL3 plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Defects in DLL3 are the cause of Spondylocostal dysostosis autosomal recessive type 1 (SCDO1). Mutations in DLL3 gene cause truncal shortening relative to their limbs, which leads to abdominal protrusion, abnormal spinal curvature and sometimes a plagiocephaly-torticollis sequence. It may be required to divert neurons along a specific differentiation pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: delta-like 3; Delta-like protein 3; Delta3; Drosophila Delta homolog 3
基因别名: DLL3; SCDO1
UniProt ID: (Human) Q9NYJ7
Entrez Gene ID: (Human) 10683