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产品信息
MA5-17068
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1/IgG2b
分类
Monoclonal
类型
Antibody
克隆号
4A11
抗原
Purified recombinant fragment of human DLL4 expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538539
产品详细信息
MA5-17068 targets DLL4 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples. This product is derived from clone #4A11F8 Mouse IgG2b and clone #4A11G2 Mouse IgG1^M
^M
The MA5-17068 immunogen is purified recombinant fragment of human DLL4 expressed in E. Coli.^M
^M
MA5-17068 detects DLL4 which has a predicted molecular weight of approximately 74.6kDa.
靶标信息
Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
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生物信息学
蛋白别名: delta 4; delta ligand 4; delta-like 4 homolog; delta-like 4 protein; Delta-like protein 4; Delta4; Drosophila Delta homolog 4; MGC126344; notch ligand delta-2; notch ligand DLL4
基因别名: AOS6; DLL4; hdelta2; UNQ1895/PRO4341
UniProt ID: (Human) Q9NR61
Entrez Gene ID: (Human) 54567
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
patterning of blood vessels
blood vessel remodeling
cardiac ventricle morphogenesis
cardiac atrium morphogenesis
ventricular trabecula myocardium morphogenesis
pericardium morphogenesis
signal transduction
Notch signaling pathway
Notch receptor processing
visual perception
blood circulation
negative regulation of cell proliferation
negative regulation of endothelial cell migration
positive regulation of gene expression
negative regulation of gene expression
T cell differentiation
dorsal aorta morphogenesis
cellular response to vascular endothelial growth factor stimulus
cellular response to fibroblast growth factor stimulus
negative regulation of Notch signaling pathway
positive regulation of Notch signaling pathway
regulation of neurogenesis
ventral spinal cord interneuron fate commitment
regulation of neural retina development
Notch signaling involved in heart development
blood vessel lumenization
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of neural precursor cell proliferation
