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DLX2 Antibody (702009) in ICC/IF
For immunofluorescence analysis, NTERA-2 cells were fixed and permeabilized for detection of endogenous DLX2 using Anti- DLX2 Recombinant Rabbit Monoclonal Antibody (Product # 702009, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of DLX2 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S369... View More
产品信息
702009
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1H13L11
抗原
Peptides corresponding to human DLX2 [1) aa127-aa141 2) aa311-aa328]
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2723069
产品详细信息
This antibody is predicted to react with Monkey, Pig, Bovine, Mouse
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DII A; distal-less homeo box 2; Homeobox protein DLX-2; Homeobox protein TES-1
基因别名: AW121999; Dlx-2; DLX2; TES-1; TES1
UniProt ID: (Human) Q07687, (Mouse) P40764
Entrez Gene ID: (Human) 1746, (Mouse) 13392
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
single-stranded RNA binding
protein binding
DNA binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
brain development
proximal/distal pattern formation
subpallium development
hippocampus development
olfactory bulb development
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
cerebral cortex GABAergic interneuron fate commitment
odontogenesis of dentin-containing tooth
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
embryonic cranial skeleton morphogenesis
negative regulation of oligodendrocyte differentiation
branching morphogenesis of a nerve
cartilage development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
forebrain neuron differentiation
cerebral cortex GABAergic interneuron differentiation
cell differentiation
embryonic skeletal system development
