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Recommended positive controls: PC-3, U87-MG, mouse testis.
Predicted reactivity: Mouse (95%), Chicken (88%), Rhesus Monkey (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cyclin D binding myb-like transcription factor 1; cyclin D binding myb-like transcription factor 1D-interacting myb-like protein; cyclin D-binding Myb-like protein; Cyclin-D-binding Myb-like transcription factor 1; Cyclin-D-interacting Myb-like protein 1; D-interacting myb-like protein; FLJ41265; hDMP1; hDMTF1; mDmp1
基因别名: Dimp; DMP1; DMTF; DMTF1; hDMP1; MRUL
UniProt ID: (Human) Q9Y222, (Mouse) Q8CE22
Entrez Gene ID: (Human) 9988, (Mouse) 23857
分子生物学功能:
DNA-binding transcription factor