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产品信息
PA5-38026
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
18 amino acid peptide near the carboxy terminus of human DNAJC13
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2554630
产品详细信息
A recommended positive control is human heart tissue lysate.
At least two isoforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is not expected to cross-react with other DNAJC family members.
靶标信息
DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans. It is thought to be a co-chaperone of Hsc70 which regulates protein conformation at membrane sites and plays a role in intracellular trafficking, co-localizing with markers of the endosomal system. Recent experiments have indicated that the DNAJC13 protein is involved in membrane trafficking through early endosomes but not through degradative organelles. DNAJC13 has been also been shown to regulate the intracellular trafficking of the epidermal growth factor receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DnaJ (Hsp40) homolog, subfamily C, member 13; DnaJ domain-containing protein RME-8; DnaJ homolog subfamily C member 13; j-domain containing protein, required for endocytosis; receptor mediated endocytosis RME-8; Required for receptor-mediated endocytosis 8; RME-8
基因别名: D030002L11Rik; DNAJC13; Gm1124; KIAA0678; mKIAA0678; PARK21; RME-8; RME8
UniProt ID: (Human) O75165
Entrez Gene ID: (Human) 23317, (Mouse) 235567
