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产品信息
DNMT3B-101AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids within region 50-100 on mouse DNA (cytosine-5)-methyltransferase 3B protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer with 20% glycerol, 0.5% BSA
内含物
0.01% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Quantity: 100 µg IgG per vial
靶标信息
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
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生物信息学
蛋白别名: DNA (cytosine-5)-methyltransferase 3B; DNA (cytosine-5-)-methyltransferase 3 beta; DNA methyltransferase 3B; DNA methyltransferase HsaIIIB; DNA methyltransferase MmuIIIB; DNA MTase HsaIIIB; DNA MTase MmuIIIB; Dnmt3; Dnmt3b; m.MmuIIIB; MGC1090
基因别名: DNMT3B; ICF; ICF1; M.HsaIIIB; MmuIIIB
UniProt ID: (Human) Q9UBC3, (Mouse) O88509
Entrez Gene ID: (Human) 1789, (Mouse) 13436, (Rat) 444985
chromatin binding
transcription corepressor activity
DNA (cytosine-5-)-methyltransferase activity
protein binding
DNA-methyltransferase activity
histone deacetylase binding
unmethylated CpG binding
metal ion binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
DNA binding
methyltransferase activity
transferase activity
DNA methyltransferase
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
DNA methylation
response to toxic substance
response to ionizing radiation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
response to caffeine
response to estradiol
response to vitamin A
response to cocaine
response to drug
positive regulation of neuron differentiation
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to hyperoxia
cellular response to dexamethasone stimulus
C-5 methylation of cytosine
methylation-dependent chromatin silencing
regulation of gene expression by genetic imprinting
protein complex localization
methylation
negative regulation of transcription, DNA-templated
inactivation of X chromosome by DNA methylation
cellular response to amino acid stimulus
