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Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: VLEALLCAET GEKKIELKEE ETIMDCQKQQ LLEFPHDLEV EDLEDDIPRR KNRAKGKAYG IGGLRKRQDT ASLEDR
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BAF45B; BRG1-associated factor 45B; D4, zinc and double PHD fingers family 1; NEU BAF45b; neuro-d4 homolog; Zinc finger protein neuro-d4
基因别名: BAF45B; DPF1; NEUD4; neuro-d4
UniProt ID: (Human) Q92782
Entrez Gene ID: (Human) 8193