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DR4 Antibody (A15746) in Flow
Oncology letters 2021 -
Figure 4. Effects of TRAIL-Mu3 on the expression levels and distribution of DRs. (A) TRAIL-Mu3 upregulated DR4 and DR5 expression in PANC-1 cells. *P<0.001 vs. TRAIL. (B) TRAIL-Mu3 and TRAIL had no effect on the distribution of DR4 in lipid rafts, while (C) TRAIL-Mu3 promoted DR5 clustering into lipid rafts. Lipid rafts were stained with FITC-conjugated rabbit anti-Ctx (green) and DR4/DR5 was counterstained... View More
产品信息
A15746
应用
建议稀释比
已发表文章
产品规格
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
DR-4-02
抗原
Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
保存条件
4° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2534526
靶标信息
TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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