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产品信息
PA5-33477
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 20 amino acid peptide from 2nd extracellular domain of human DRD1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550857
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%) Gibbon, Marmoset (95%) Elephant (90%) Dog, Rabbit (85%) Horse (80%).
This antibody is not recommended for use in ICC/IF and IHC (F).
靶标信息
The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(1A) dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor
基因别名: DADR; DRD1; DRD1A
UniProt ID: (Human) P21728
Entrez Gene ID: (Human) 1812
dopamine neurotransmitter receptor activity, coupled via Gs
G-protein alpha-subunit binding
dopamine neurotransmitter receptor activity
protein binding
drug binding
protein phosphatase binding
angiotensin receptor binding
D3 dopamine receptor binding
protein complex binding
dopamine binding
protein heterodimerization activity
ATPase binding
G-protein coupled receptor
temperature homeostasis
conditioned taste aversion
behavioral fear response
synaptic transmission, dopaminergic
response to amphetamine
negative regulation of protein kinase activity
protein import into nucleus
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
synapse assembly
learning
memory
mating behavior
grooming behavior
adult walking behavior
visual learning
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
astrocyte development
response to activity
dopamine transport
transmission of nerve impulse
neuronal action potential
regulation of vasoconstriction
calcium-mediated signaling
dentate gyrus development
striatum development
orbitofrontal cortex development
cerebral cortex GABAergic interneuron migration
positive regulation of cell migration
negative regulation of cell migration
peristalsis
positive regulation of cAMP biosynthetic process
response to food
response to estradiol
response to retinoic acid
cellular response to insulin stimulus
response to nicotine
operant conditioning
social behavior
response to antidepressant
regulation of dopamine metabolic process
vasodilation
negative regulation of circadian sleep/wake cycle, sleep
dopamine metabolic process
response to drug
maternal behavior
response to amino acid
positive regulation of potassium ion transport
response to morphine
response to ethanol
positive regulation of membrane potential
glucose import
habituation
sensitization
behavioral response to cocaine
regulation of long-term neuronal synaptic plasticity
response to steroid hormone
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
regulation of dopamine uptake involved in synaptic transmission
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
phospholipase C-activating dopamine receptor signaling pathway
long-term synaptic potentiation
long term synaptic depression
cellular response to hypoxia
cellular response to catecholamine stimulus
positive regulation of long-term synaptic potentiation
positive regulation of feeding behavior
