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Invitrogen
DRD1 Monoclonal Antibody (SG2-D1a)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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DRD1 Antibody (MA1-46024) in WB
Western blot analysis of DRD1 in lysates from Sf9 cells. Samples were incubated in DRD1 monoclonal antibody (Product # MA1-46024). transfected with rat DR-D1b (Lane 1) or DR-D1a (Lane 2) using DRD1 antibody (clone SG2-D1a). This clone detected D1a receptor only and was not cross-reactive against DR-D1b.
产品信息
MA1-46024
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Marsupial
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
SG2-D1a
抗原
Recombinant rat D1a dopamine receptor (123 residues with 23 residues near the C-terminus).[Swiss-Prot# P18901]
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2261891
产品详细信息
This antibody does not react with human, canine, porcine, sheep, rabbit, or bovine.
靶标信息
The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: D(1A) dopamine receptor; D1 receptor; D1A dopamine receptor; D1a receptor; Dopamine 1 receptor; Dopamine D1 receptor; dopamine receptor D1A; Dopamine-1A receptor; G protein-coupled receptor DRD1
基因别名: C030036C15Rik; D1a; Drd-1; Drd1; Drd1a; Gpcr15
UniProt ID: (Mouse) Q61616
Entrez Gene ID: (Mouse) 13488, (Rat) 24316
dopamine neurotransmitter receptor activity, coupled via Gs
G-protein alpha-subunit binding
signal transducer activity
G-protein coupled receptor activity
dopamine neurotransmitter receptor activity
receptor binding
protein binding
drug binding
G-protein coupled amine receptor activity
protein phosphatase binding
angiotensin receptor binding
D3 dopamine receptor binding
protein complex binding
dopamine binding
protein heterodimerization activity
ATPase binding
G-protein coupled receptor
temperature homeostasis
conditioned taste aversion
behavioral fear response
synaptic transmission, dopaminergic
startle response
response to amphetamine
negative regulation of protein kinase activity
protein import into nucleus
intracellular protein transport
muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
adenylate cyclase-activating dopamine receptor signaling pathway
dopamine receptor signaling pathway
chemical synaptic transmission
sensory perception of chemical stimulus
learning
memory
mating behavior
grooming behavior
locomotory behavior
adult walking behavior
feeding behavior
associative learning
visual learning
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
astrocyte development
dopamine transport
transmission of nerve impulse
neuronal action potential
regulation of vasoconstriction
calcium-mediated signaling
dentate gyrus development
striatum development
hippocampus development
cerebral cortex GABAergic interneuron migration
positive regulation of cell migration
negative regulation of cell migration
peristalsis
positive regulation of cAMP biosynthetic process
phosphatidylinositol catabolic process
operant conditioning
social behavior
regulation of dopamine metabolic process
response to cocaine
vasodilation
negative regulation of circadian sleep/wake cycle, sleep
response to drug
maternal behavior
regulation of ion transport
positive regulation of adenylate cyclase activity
positive regulation of membrane potential
glucose import
phosphatidylinositol metabolic process
habituation
sensitization
behavioral response to cocaine
regulation of long-term neuronal synaptic plasticity
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of synaptic transmission, glutamatergic
prepulse inhibition
phospholipase C-activating dopamine receptor signaling pathway
long-term synaptic potentiation
long term synaptic depression
cellular response to catecholamine stimulus
positive regulation of long-term synaptic potentiation
positive regulation of feeding behavior
synapse assembly
response to organonitrogen compound
response to organic cyclic compound
response to activity
orbitofrontal cortex development
response to food
response to estradiol
response to retinoic acid
cellular response to insulin stimulus
response to nicotine
response to antidepressant
response to amino acid
response to morphine
response to ethanol
response to steroid hormone
cellular response to hypoxia
