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DRD3 Antibody (PA5-115143) in ICC/IF
Immunocytochemistry analysis of DRD3 in HepG2 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115143) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115143
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DRD3(Accession P35462), corresponding to amino acid residues K281-V331.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899779
产品详细信息
Antibody detects endogenous levels of total DRD3.
靶标信息
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(3) dopamine receptor; D3 receptor; D3nf; Dopamine 3 receptor; Dopamine D3 receptor; dopamine receptor 3; dopaminergic receptor D3; essential tremor 1
基因别名: D3DR; D3R; DRD3; ETM1; FET1
UniProt ID: (Human) P35462, (Rat) P19020, (Mouse) P30728
Entrez Gene ID: (Human) 1814, (Rat) 29238, (Mouse) 13490
dopamine neurotransmitter receptor activity, coupled via Gs
dopamine neurotransmitter receptor activity, coupled via Gi/Go
protein binding
drug binding
protein domain specific binding
D1 dopamine receptor binding
dopamine binding
dopamine neurotransmitter receptor activity
signal transducer activity
G-protein coupled receptor activity
G-protein coupled amine receptor activity
G-protein coupled receptor
negative regulation of transcription from RNA polymerase II promoter
synaptic transmission, dopaminergic
response to amphetamine
regulation of blood volume by renin-angiotensin
G-protein coupled receptor internalization
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting dopamine receptor signaling pathway
learning or memory
learning
locomotory behavior
positive regulation of cell proliferation
visual learning
regulation of dopamine secretion
regulation of lipid metabolic process
regulation of cAMP metabolic process
negative regulation of sodium:proton antiporter activity
positive regulation of cytokinesis
circadian regulation of gene expression
response to histamine
social behavior
gastric emptying
positive regulation of renal sodium excretion
regulation of multicellular organism growth
response to cocaine
dopamine metabolic process
response to drug
response to morphine
regulation of circadian sleep/wake cycle, sleep
response to ethanol
negative regulation of blood pressure
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
acid secretion
behavioral response to cocaine
negative regulation of oligodendrocyte differentiation
arachidonic acid secretion
negative regulation of protein secretion
musculoskeletal movement, spinal reflex action
regulation of dopamine uptake involved in synaptic transmission
negative regulation of protein kinase B signaling
prepulse inhibition
negative regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of locomotion involved in locomotory behavior
dopamine receptor signaling pathway
chemical synaptic transmission
regulation of locomotion
signal transduction
sensory perception of chemical stimulus
