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Immunogen sequence: MKAVVQRVT RASVTVGGEQ ISAIGRGICV LLGISLEDTQ KELEHMVRKI LNLRVFEDES GKHWSKSVMD KQYEILCVSQ FTLQCVLKGN KPDFNLAMPT EQAEGFYNSF LEQLRKTYRP ELIKDGKFGA YMQVHIQNDG PVTIELESPA PGTATSDPKQ LSKLEKQQQR KEKTRAKGPS ESSKERNTPR KEDRSASSGA EGDVSSEREP (1-209 aa encoded by BC045167)
Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis. It is a holoenzyme shell (approximately 450 kDa) consisting of 24 subunits of two types, H (heavy) and L (light), and capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiologic status of the cell, the ratio of H to L subunits in ferritin can vary widely. It can be viewed not only as part of a group of iron regulatory proteins that include transferrin and the transferrin receptor, but also as a member of the protein family that orchestrates the cellular defense against stress and inflammation. Ferritin is found in the liver, spleen, kidney and heart. Only a small amount is found in the blood. The blood level of ferritin serves as an indicator of the amount of iron stored in the body.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: bA379J5.3; bA555E18.1; D-aminoacyl-tRNA deacylase 1; D-tyrosyl-tRNA deacylase 1 homolog; D-tyrosyl-tRNA(Tyr) deacylase 1; DNA-unwinding element-binding protein B; DTD; DUE-B; Gly-tRNA(Ala) deacylase; histidyl tRNA synthetase 2; Histidyl-tRNA synthase-related; histidyl-tRNA synthetase 2; MGC119131; MGC41905
基因别名: 0610006H08Rik; C20orf88; DTD1; DUE-B; DUEB; HARS2; pqn-68
UniProt ID: (Human) Q8TEA8, (Mouse) Q9DD18
Entrez Gene ID: (Human) 92675, (Mouse) 66044, (Rat) 362227
分子生物学功能:
esterase
hydrolase
metabolite interconversion enzyme