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This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
DUSP7 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dual specificity protein phosphatase 7; Dual specificity protein phosphatase MKP-X; MAP kinase phosphatase
基因别名: Dusp7; mkp-X; Mkpx
UniProt ID: (Rat) Q63340
Entrez Gene ID: (Rat) 300980
分子生物学功能: protein phosphatase