Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
H00001855-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DVL1 (NP_877580.1, 1 a.a. approximately 444 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK SMDQDFGVVK EEIFDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDSHT DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESM VSHRRERARR RNREEAARTN GHPRGDRRRD VGLPPDSAST ALSSELESSS FVDSDEDGST SRLSSSTEQS TSSRLTRKYA SSLLKHGFLR HTVNKITFSE QCYYVFGDLC SNLATLNLNS GSSGTSDQDT LAPLPHPAAP WPLGQGYPYQ YPGPPPCFPP AYQDPGFSYG SGSTGSQQSE GSKSSGSTRS SRRAPGREKE RRAAGAGGSG SESDHTAPSG VGSSWRERPA GQLSRGSSPR SQASATAPGL PPPHPTTKAY TVVGGPPGGP PVRELAAVPP ELTGSRQSFQ KAMGNPCEFF VDIM
靶标信息
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: dishevelled 1 (homologous to Drosophila dsh); dishevelled, dsh homolog 1; Dishevelled-1; Dishevelled-1-like; DSH homolog 1; DSH homolog 1-like; MGC54245; RP5-890O3.5; Segment polarity protein dishevelled homolog DVL-1
基因别名: DRS2; DVL; DVL1; DVL1L1; DVL1P1
UniProt ID: (Human) O14640
Entrez Gene ID: (Human) 1855
regulation of neurotransmitter levels
positive regulation of protein phosphorylation
transcription from RNA polymerase II promoter
negative regulation of protein kinase activity
neurotransmitter secretion
axon guidance
synapse assembly
heart development
neuromuscular junction development
positive regulation of neuron projection development
neural tube development
convergent extension involved in neural plate elongation
positive regulation of Wnt signaling pathway
cytoplasmic microtubule organization
negative regulation of protein binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
social behavior
protein localization to microtubule
intracellular signal transduction
receptor clustering
positive regulation of transcription, DNA-templated
collateral sprouting
axon extension
dendrite morphogenesis
synapse organization
protein stabilization
canonical Wnt signaling pathway
Wnt signaling pathway, planar cell polarity pathway
prepulse inhibition
skeletal muscle acetylcholine-gated channel clustering
negative regulation of canonical Wnt signaling pathway
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
positive regulation of canonical Wnt signaling pathway
positive regulation of protein localization to synapse
regulation of cellular protein localization
beta-catenin destruction complex disassembly
