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产品信息
PA5-65448
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2663063
产品详细信息
Immunogen sequence: AFVVDEVSNIV KEAIESAIGG NAYQHSKVNQ WTTNVVEQTL SQLTKLGKPF KYIVTCVIMQ KNGAGLHTAS S
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 100%.
靶标信息
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dynein light chain Tctex-type 1; dynein, light chain, Tctex-type 1; Protein CW-1; T-complex testis-specific protein 1 homolog; t-complex-associated-testis-expressed 1-like 1
基因别名: CW-1; DYNLT1; TCTEL1; TCTEX-1; TCTEX1
UniProt ID: (Human) P63172
Entrez Gene ID: (Human) 6993
establishment of mitotic spindle orientation
mitotic nuclear division
regulation of G-protein coupled receptor protein signaling pathway
intracellular transport of viral protein in host cell
regulation of GTPase activity
viral entry into host cell
neuron projection morphogenesis
negative regulation of neurogenesis
cell division
regulation of cytoskeleton organization
microtubule-dependent intracellular transport of viral material towards nucleus
