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产品信息
DYRK2-FITC
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 550-601 on human Dual specificity tyrosine-phosphorylation-regulated kinase 2.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
DYRK2 (also known as dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2) belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development and is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 expressed in E. coli demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. DYRK2 also regulates p53 to induce apoptosis in response to DNA damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dual specificity tyrosine-(Y)-phosphorylation regulated kinase 2; Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; dyrk2
基因别名: 1810038L18Rik; DYRK2
UniProt ID: (Human) Q92630, (Mouse) Q5U4C9
Entrez Gene ID: (Human) 8445, (Mouse) 69181, (Rat) 314862
magnesium ion binding
protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
manganese ion binding
ubiquitin binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
apoptotic process
smoothened signaling pathway
phosphorylation
peptidyl-tyrosine phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of glycogen biosynthetic process
negative regulation of NFAT protein import into nucleus
cellular response to DNA damage stimulus
regulation of signal transduction by p53 class mediator
