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Defensin alpha-1 is part of a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. Defensins are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The Defensin alpha-1 protein is encoded by the DFA1 gene and is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8, and this gene differs from defensin, alpha 3 by only one amino acid. The DFA1 gene and the gene encoding defensin, alpha 3 are both subject to copy number variation. Two transcript variants encoding different isoforms of Defensin alpha-1 have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: defensin 3, neutrophil-specific; Defensin, alpha 3; defensin, alpha 3, neutrophil-specific; HNP-3; HP-3; Neutrophil defensin 3; neutrophil peptide 3
基因别名: DEF3; DEFA3; HNP-3; HNP3; HP-3; HP3
UniProt ID: (Human) P59666
Entrez Gene ID: (Human) 1668
分子生物学功能:
antimicrobial response protein