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DP2.17 shows distinct punctate membrane staining of epithelia. DP2.17 reacts with the rod fragment of desmoplakin 1. Polypeptide reacting: Desmoplakin no. 1 (MW 250,000 polypeptide of desmosomal plaques) Reactivity on cultured cell lines: Several human carcinoma cell lines, such as MCF-7, A-431, TR-146; bovine cells: MDBK, BMGE Tumors specifically detected: Primary and metastatic carcinoma; meningioma.
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; desmoplakin I/II; Desmoplakin II; Desmoplakin-I; desmosomal cytoskeletal connector molecule; DP
基因别名: 2300002E22Rik; 5730453H04Rik; AA407887; AA407888; AW109828; DCWHKTA; DP; DSP; rul
UniProt ID: (Human) P15924, (Mouse) E9Q557
Entrez Gene ID: (Human) 1832, (Bovine) 514360, (Chicken) 420869, (Mouse) 109620, (Rat) 306871