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Invitrogen
Desmoplakin Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-63041
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2640538
产品详细信息
Immunogen sequence: RELDECFAQA NDQMEILDSL IREMRQMGQP CDAYQKRLLQ LQEQMRALYK AISVPRVRRA SSKGGGGYTC QSGSGWDEFT KHVTSECLGW
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 89%.
靶标信息
Desmoplakin (DSP) is a major high molecular weight protein of the desmosomes. It is involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Desmoplakin mutations are associated with Keratoderma and cardiomyopathy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 250/210 kDa paraneoplastic pemphigus antigen; Desmoplakin; Desmoplakin II; Desmoplakin-I; DP
基因别名: DCWHKTA; DP; DSP
UniProt ID: (Human) P15924
Entrez Gene ID: (Human) 1832
protein kinase C binding
structural molecule activity
structural constituent of cytoskeleton
protein binding
protein binding, bridging
poly(A) RNA binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
scaffold protein binding
intermediate filament binding protein
desmosome organization
ventricular compact myocardium morphogenesis
epidermis development
peptide cross-linking
keratinocyte differentiation
adherens junction organization
wound healing
intermediate filament organization
protein localization to adherens junction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
regulation of ventricular cardiac muscle cell action potential
