Invitrogen

Doublecortin Monoclonal Antibody (01)

Doublecortin Antibody in Immunocytochemistry (ICC/IF)

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Doublecortin Antibody (MA5-43039) in ICC/IF

Immunocytochemistry analysis of Doublecortin in HepG2 cells. Samples were treated with 4% PFA, permeabilized with 1% Triton X-100 in PBS, and blocked with 10% serum, incubated in Doublecortin monoclonal antibody (Product # MA5-43039) at a dilution of 1:60, followed by Alexa Fluor 594-conjugated Goat Anti-mouse IgG and DAPI.

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产品信息

MA5-43039

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

1:20-1:100

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

抗原

Recombinant Human Doublecortin/DCX Protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2912179

产品详细信息

Specificity: Human Doublecortin/DCX

靶标信息

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

仅用于科研。不用于诊断过程。未经明确授权不得转售。