Invitrogen

Dystrophin Polyclonal Antibody

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抗体检测数据 (3)

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Dystrophin Antibody (PA5-110894) in IHC (P)

Immunohistochemical analysis of Dystrophin in human skeletal muscle using Dystrophin Polyclonal Antibody (Product # PA5-110894) shows strong membranous positivity in myocytes.

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Dystrophin in human skeletal muscle using Dystrophin Polyclonal Antibody (Product # PA5-110894) shows strong membranous positivity in myocytes.

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Dystrophin in human heart muscle using Dystrophin Polyclonal Antibody (Product # PA5-110894) shows strong membranous positivity in myocytes.

Dystrophin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of Dystrophin in human tonsil using Dystrophin Polyclonal Antibody (Product # PA5-110894) shows no positivity in lymphoid cells as expected.

产品信息

PA5-110894

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:1,000-1:2,500

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant Protein corresonding to Human Dystrophin. Recombinant protein control fragment (Product #RP-92153).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2856305

产品详细信息

Immunogen sequence: KQNDVHRAFK RELKTKEPVI MSTLETVRIF LTEQPLEGLE KLYQEPRELP PEERAQNVTR LLRKQAEEVN TEWEKLNLHS ADWQRKIDET LERLQELQEA TDELDLKLRQ AEVIKGSWQP VGDLLIDSLQ DHLEKVKALR GEIAPLKENV

靶标信息

Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Duchenne muscular dystrophy (DMD); Dystrophin; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; OTTHUMP00000215592

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基因别名: BMD; CMD3B; DMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; MRX85

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UniProt ID: (Human) P11532

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Entrez Gene ID: (Human) 1756

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dystroglycan binding actin binding structural constituent of cytoskeleton protein binding zinc ion binding structural constituent of muscle myosin binding vinculin binding nitric-oxide synthase binding ubiquitin-protein ligase

参与通路

regulation of heart rate cytoskeleton organization muscle organ development regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction muscle attachment muscle filament sliding negative regulation of peptidyl-serine phosphorylation cellular protein localization response to muscle stretch peptide biosynthetic process cellular protein complex assembly muscle cell cellular homeostasis muscle fiber development cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity cardiac muscle cell action potential regulation of voltage-gated calcium channel activity negative regulation of peptidyl-cysteine S-nitrosylation positive regulation of sodium ion transmembrane transporter activity