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产品信息
A700-088
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR088G
抗原
Recombinant protein representing the extracellular domain of human E-Cadherin (residues 155-707).
偶联物
形式
Liquid
浓度
250 µg/mL
纯化类型
purified
保存液
BBS, pH 7.8 to 8.6, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
靶标信息
E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARC-1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; Cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Ecadherin; Epithelial cadherin; Uvomorulin
基因别名: AA960649; Arc-1; CD324; CDH1; CDHE; E-cad; ECAD; L-CAM; LCAM; Um; UVO
UniProt ID: (Human) P12830, (Mouse) P09803
Entrez Gene ID: (Human) 999, (Mouse) 12550
glycoprotein binding
calcium ion binding
protein binding
beta-catenin binding
ankyrin binding
GTPase activating protein binding
gamma-catenin binding
cell adhesion molecule binding
cadherin binding involved in cell-cell adhesion
protein phosphatase binding
protein domain specific binding
metal ion binding
cadherin
homophilic cell adhesion via plasma membrane adhesion molecules
synapse assembly
response to toxic substance
single organismal cell-cell adhesion
pituitary gland development
negative regulation of cell-cell adhesion
extracellular matrix disassembly
extracellular matrix organization
neuron projection development
adherens junction organization
response to drug
positive regulation of transcription factor import into nucleus
positive regulation of transcription, DNA-templated
cellular response to lithium ion
cellular response to indole-3-methanol
protein localization to plasma membrane
establishment of protein localization to plasma membrane
in utero embryonic development
trophectodermal cell differentiation
epithelial cell morphogenesis
cell adhesion
sensory perception of sound
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
protein metabolic process
regulation of protein localization
regulation of water loss via skin
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
protein homooligomerization
intestinal epithelial cell development
salivary gland cavitation
regulation of branching involved in salivary gland morphogenesis
bicellular tight junction assembly
cellular response to amino acid stimulus
negative regulation of canonical Wnt signaling pathway
cochlea development
regulation of protein localization to cell surface
regulation of neuron migration
