Proteintech

ECHS1 Monoclonal Antibody (2B9D5)

ECHS1 Antibody in Immunocytochemistry (ICC/IF)

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ECHS1 Antibody (66117-1-IG) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 66117-1-IG (ECHS1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IGG (H+L).

ECHS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ECHS1 Antibody in Immunoprecipitation (IP)

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产品信息

66117-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000-1:20,000

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免疫组化（石蜡） (IHC (P))

1:50-1:1,000

免疫细胞化学 (ICC/IF)

1:20-1:200

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免疫沉淀 (IP)

0.5-4.0 µg

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

2B9D5

抗原

ECHS1 Fusion Protein Ag16775 (1-290 aa encoded by BC008906)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.21 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MAALRVLLS CVRGPLRPPV RCPAWRPFAS GANFEYIIAE KRGKNNTVGL IQLNRPKALN ALCDGLIDEL NQALKIFEED PAVGAIVLTG GDKAFAAGAD IKEMQNLSFQ DCYSSKFLKH WDHLTQVKKP VIAAVNGYAF GGGCELAMMC DIIYAGEKAQ FAQPEILIGT IPGAGGTQRL TRAVGKSLAM EMVLTGDRIS AQDAKQAGLV SKICPVETLV EEAIQCAEKI ASNSKIVVAM AKESVNAAFE MTLTEGSKLE KKLFYSTFAT DDRKEGMTAF VEKRKANFKD Q (1-290 aa encoded by BC008906)

靶标信息

The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The role of SAMM50 in non-alcoholic fatty liver disease: from genetics to mechanisms.

FEBS open bio

Li Z,Shen W,Wu G,Qin C,Zhang Y,Wang Y,Song G,Xiao C,Zhang X,Deng G,Wang R,Wang X

Thu Jul 01 00:00:00 EDT 2021

ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.

Cell death & disease

Li R,Hao Y,Wang Q,Meng Y,Wu K,Liu C,Xu L,Liu Z,Zhao L

Wed Oct 06 00:00:00 EDT 2021

ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.

Cell death & disease

Li R,Hao Y,Wang Q,Meng Y,Wu K,Liu C,Xu L,Liu Z,Zhao L

Wed Oct 06 00:00:00 EDT 2021

ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.

Cell death & disease

Li R,Hao Y,Wang Q,Meng Y,Wu K,Liu C,Xu L,Liu Z,Zhao L

Wed Oct 06 00:00:00 EDT 2021

Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement.

Annals of clinical and translational neurology

Haack TB,Jackson CB,Murayama K,Kremer LS,Schaller A,Kotzaeridou U,de Vries MC,Schottmann G,Santra S,Büchner B,Wieland T,Graf E,Freisinger P,Eggimann S,Ohtake A,Okazaki Y,Kohda M,Kishita Y,Tokuzawa Y,Sauer S,Memari Y,Kolb-Kokocinski A,Durbin R,Hasselmann O,Cremer K,Albrecht B,Wieczorek D,Engels H,Hahn D,Zink AM,Alston CL,Taylor RW,Rodenburg RJ,Trollmann R,Sperl W,Strom TM,Hoffmann GF,Mayr JA,Meitinger T,Bolognini R,Schuelke M,Nuoffer JM,Kölker S,Prokisch H,Klopstock T

Fri May 01 00:00:00 EDT 2015

Deficiency of ECHS1 causes mitochondrial encephalopathy with cardiac involvement.

Annals of clinical and translational neurology

Fri May 01 00:00:00 EDT 2015

Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study.

Journal of proteomics

Xu WD,Yang XY,Li DH,Zheng KD,Qiu PC,Zhang W,Li CY,Lei KF,Yan GQ,Jin SW,Wang JG

Thu Jan 15 00:00:00 EST 2015

Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study.

Journal of proteomics

Xu WD,Yang XY,Li DH,Zheng KD,Qiu PC,Zhang W,Li CY,Lei KF,Yan GQ,Jin SW,Wang JG

Thu Jan 15 00:00:00 EST 2015

生物信息学

蛋白别名: ECHS1; enoyl CoA hydratase, short chain, 1, mitochondrial; enoyl Coenzyme A hydratase, short chain, 1, mitochondrial; Enoyl-CoA hydratase 1; Enoyl-CoA hydratase, mitochondrial; enoyl-CoA hydratase, short chain, 1, mitochondrial; mECH; SCEH; short chain enoyl-CoA hydratase; Short-chain enoyl-CoA hydratase

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基因别名: ECHS1; ECHS1D; SCEH

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UniProt ID: (Human) P30084

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Entrez Gene ID: (Human) 1892

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功能

enoyl-CoA hydratase activity protein binding hydratase

参与通路

fatty acid beta-oxidation