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Immunogen sequence: EDNPVHKSG TRYMFTTEGH IVSVDEHLRE LPWKEFFSEE GGQDQGGKSV HRPKPHELKV INSSSNCNRV PDERRYSLPL KSIYMRQIDQ MVGLI (564-657 aa encoded by BC019088)
EDEM1 belongs to the glycosyl hydrolase 47 family. It extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ER degradation enhancer, mannosidase alpha-like 1; ER degradation ER degradation enhancer, mannosidase alpha-like 1; ER degradation-enhancing alpha-mannosidase-like 1; ER degradation-enhancing alpha-mannosidase-like protein 1
基因别名: A130059K23Rik; EDEM; EDEM1; KIAA0212; mKIAA0212; RGD1563633
UniProt ID: (Human) Q92611, (Mouse) Q925U4
Entrez Gene ID: (Human) 9695, (Mouse) 192193, (Rat) 297504