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EFHA1 Antibody (PA5-88410) in WB
Western blot analysis of EFHA1 in extracts of various cell lines. Samples were incubated with EFHA1 Polyclonal antibody (Product # PA5-88410) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-88410
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MICU2 (NP_6899391)
偶联物
形式
Liquid
浓度
2.58 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804893
产品详细信息
Positive Samples: 293T, Mouse skeletal muscle, Rat skeletal muscle; Cellular Location: Mitochondrion intermembrane space
Immunogen sequence: TNETGYQEAI VKEPEIN
靶标信息
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calcium uptake protein 2, mitochondrial; EF hand domain family A1; EF hand domain family, member A1; EF-hand domain family member A1; EF-hand domain family, member A1; EF-hand domain-containing family member A1; hMICU3; Smhs2 homolog
基因别名: 1110008L20Rik; EFHA1; MICU2
UniProt ID: (Human) Q8IYU8
Entrez Gene ID: (Human) 221154
