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EIF5A2 Polyclonal Antibody

EIF5A2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EIF5A2 Antibody (17069-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using (Product # 17069-1-AP) (EIF5A1/EIF5A2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

EIF5A2 Antibody in Immunoprecipitation (IP)

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产品信息

17069-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

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免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

EIF5A2 Fusion Protein Ag10895 (1-153 aa encoded by BC036072)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MADEIDFTT GDAGASSTYP MQCSALRKNG FVVLKGRPCK IVEMSTSKTG KHGHAKVHLV GIDIFTGKKY EDICPSTHNM DVPNIKRNDY QLICIQDGYL SLLTETGEVR EDLKLPEGEL GKEIEGKYNA GEDVQVSVMC AMSEEYAVAI KPCK (1-153 aa encoded by BC036072)

靶标信息

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

High eukaryotic initiation factor 5A2 expression predicts poor prognosis and may participate in the SNHG16/miR-10b-5p/EIF5A2 regulatory axis in head and neck squamous cell carcinoma.

Journal of clinical laboratory analysis

Ye S,Wang D,Jin M,Du J,Chen X,Zhang H,Zhou C,Fang S,Liu K

Sun Jan 01 00:00:00 EST 2023

Eukaryotic Initiation Factor 5A2 Regulates Expression of Antiviral Genes.

Journal of molecular biology

Farache D,Liu L,Lee ASY

Mon May 30 00:00:00 EDT 2022

Global analyses of mRNA expression in human sensory neurons reveal eIF5A as a conserved target for inflammatory pain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chase R,de la Peña JB,Smith PR,Lawson J,Lou TF,Stanowick AD,Black BJ,Campbell ZT

Fri Jul 01 00:00:00 EDT 2022

Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission.

PLoS biology

Ma D,Zheng B,Liu HL,Zhao YB,Liu X,Zhang XH,Li Q,Shi WB,Suzuki T,Wen JK

Sat Aug 01 00:00:00 EDT 2020

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 EDT 2018

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 EDT 2018

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 EDT 2018

Knockdown of EIF5A2 inhibits the malignant potential of non-small cell lung cancer cells.

Oncology letters

Chen C,Zhang B,Wu S,Song Y,Li J

Sun Apr 01 00:00:00 EDT 2018

EIF5A2 is a novel chemoresistance gene in breast cancer.

Breast cancer (Tokyo, Japan)

Liu Y,Du F,Chen W,Yao M,Lv K,Fu P

Sun Nov 01 00:00:00 EDT 2015

EIF5A2 is a novel chemoresistance gene in breast cancer.

Breast cancer (Tokyo, Japan)

Liu Y,Du F,Chen W,Yao M,Lv K,Fu P

Sun Nov 01 00:00:00 EDT 2015

Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.

BMC pulmonary medicine

Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

Fri Nov 07 00:00:00 EST 2014

Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2.

BMC pulmonary medicine

Xu G,Yu H,Shi X,Sun L,Zhou Q,Zheng D,Shi H,Li N,Zhang X,Shao G

Fri Nov 07 00:00:00 EST 2014

Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells.

Journal of Zhejiang University. Science. B

Xu GD,Shi XB,Sun LB,Zhou QY,Zheng DW,Shi HS,Che YL,Wang ZS,Shao GF

Sat Jun 01 00:00:00 EDT 2013

Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells.

Journal of Zhejiang University. Science. B

Xu GD,Shi XB,Sun LB,Zhou QY,Zheng DW,Shi HS,Che YL,Wang ZS,Shao GF

Sat Jun 01 00:00:00 EDT 2013

Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression.

PloS one

Jin Y,Liu Z,Cao W,Ma X,Fan Y,Yu Y,Bai J,Chen F,Rosales J,Lee KY,Fu S

Mon Sep 24 00:00:00 EDT 2012

Novel functional MAR elements of double minute chromosomes in human ovarian cells capable of enhancing gene expression.

PloS one

Jin Y,Liu Z,Cao W,Ma X,Fan Y,Yu Y,Bai J,Chen F,Rosales J,Lee KY,Fu S

Mon Sep 24 00:00:00 EDT 2012

生物信息学

蛋白别名: eIF-5A-2; eIF-5A2; eukaryotic initiation factor 5A; Eukaryotic initiation factor 5A isoform 2; Eukaryotic translation initiation factor 5A-2

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基因别名: 9630038B20; EIF-5A2; EIF5A2; eIF5AII

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UniProt ID: (Human) Q9GZV4, (Mouse) Q8BGY2

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Entrez Gene ID: (Human) 56648, (Rat) 310261, (Mouse) 208691

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功能

translation elongation factor activity protein binding ribosome binding translation initiation factor activity RNA binding translation initiation factor

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